[13] He earned his PhD degree in chemistry in 1986 as a postgraduate student of Churchill College, Cambridge and was supervised by Ian William Murison Smith.

[14][1][13] After his doctorate, Klenerman went to Stanford University as a Fulbright scholar to work on high-overtone chemistry, with Richard Zare.

[10][23][24] Most recently, his group is focusing on 3D super-resolution microscopy to develop new insights on protein misfolding and neurodegenerative diseases.

[11] Klenerman and Shankar Balasubramanian commercialised their invention on the single-molecule-fluorescence based high-speed DNA sequencing and jointly founded Solexa in 1998.

[5][25][26][27][28] In 2004, Klenerman co-founded another spin-out company, Ionscope, to supply assembled scanning ion-conductance microscopes to the research community that looks for high-resolution 3D images of live cells.