Sir David Lewis Macpherson, KCMG PC (September 12, 1818 – August 16, 1896) was a Canadian businessman and political figure.

[1] He became a clerk in the Montreal office of his older brother's shipping business, which transported passengers and freight in Upper and Lower Canada.

In 1864, he was elected to the Legislative Council of the Province of Canada for Saugeen division and, in 1867, he was appointed to the Senate as a Conservative and served until his death.

Macpherson was a member of the arbitration board that dealt with the financial issues associated with the creation of the separate provinces of Ontario and Quebec after Confederation.

On the day that the bill received its second reading in the Red Chamber, Macpherson invited Mrs. Susan Anna Wiggins, whose 'The Gunhilda Letters: Marriage with a Deceased Wife's Sister' letters of support for the bill had gained attention, to take a seat on his right, an honour which was never before accorded to any woman but the wife of a Governor-General.

[1] In later life, Macpherson suffered from diabetes and he spent part of the summer and fall each year recovering at spas in Germany.

Problems with land policy, unwillingness to take action and a basic lack of understanding in Macpherson's ministry of the concerns of the Métis people helped set the stage for the North-West Rebellion in 1885.

The Honourable William Miller, K.C., pronounced in the Senate a tribute to Sir David and Lady Macpherson after the former's death.