"[4] Lindsay-Abaire had his first theatrical success with Fuddy Meers, which was workshopped as part of the National Playwrights Conference at the Eugene O'Neill Theatre Center in 1998 under Artistic Director Lloyd Richards.

[8][9] He returned to the Manhattan Theatre Club in 2001 with Wonder of the World, starring Sarah Jessica Parker, about a wife who suddenly leaves her husband and hops a bus to Niagara Falls in search of freedom, enlightenment, and the meaning of life.

[15] His play Rabbit Hole premiered in 2006 on Broadway with Cynthia Nixon, Tyne Daly, and John Slattery,[16] and won the 2007 Pulitzer Prize for Drama.

[23] Good People officially opened on Broadway on March 3, 2011, with Frances McDormand and Tate Donovan in the lead roles.

Directed by David Hyde Pierce, the cast features Marylouise Burke, Rachel Dratch, Glenn Fitzgerald, and Holland Taylor.

[citation needed] In 2021, Lindsay-Abaire adapted his 2000 play Kimberly Akimbo into a musical of the same name, with a score by Jeanine Tesori.

[29] His other screenplays have tended to be in the children's fantasy and science fiction genres, including the animated film Robots (2005),[30] written with Lowell Ganz and Babaloo Mandel, Inkheart (2008), based on the novel of the same name,[31] the animated film Rise of the Guardians (2012),[32] based on a story by children's author, illustrator and filmmaker William Joyce, who was originally attached to direct the film before stepping down to serve as executive producer[citation needed], and Oz the Great and Powerful (2013), written with Mitchell Kapner.