Lofton has also been a member of the Hamilton Tiger-Cats, Toronto Argonauts and New York Sentinels.
In the spring of 2003, he converted to the wide receiver position but saw limited playing time though he did catch two balls for 10 yards in the season finale.
Lofton played in all 11 games of the 2005 Cardinals season including five weeks as the starting free safety, finishing the year with 35 total tackles and one tackle-for-loss.
Lofton then signed with the Hamilton Tiger-Cats of the Canadian Football League as a free agent on September 12 and dressed for four games (four starts) of the 2007 CFL season making 17 defensive tackles, 1 special teams tackle, and 1 quarterback sack.
David Lofton gave his father's Pro Football Hall of Fame induction speech in 2003.