[25] On June 26, 2018, it was announced that Dee Harris-Lawrence will be the showrunner and set to serve as an executive producer along with Tarell Alvin McCraney, Mike Kelley, Melissa Loy, Michael B. Jordan, and Oprah Winfrey.

[32] In June 2018, it was announced that Akili McDowell, Phylicia Rashad, Nathaniel Logan McIntyre, Isaiah Johnson, Ade Chike Torbert, Jordan Bolger, Cayden K. Williams, and Travis Coles are cast as series regulars.

[33] On October 25, 2018, Lela Rochon, Trace Lysette, Liza Colón-Zayas, Juanita Jennings, Lindsey Blackwell, Solomon Valdez, Teshi Thomas, and newcomers Nick Creegan, Kimaya Naomi and Logan Rozos have joined the series in recurring roles.

[2] On December 8, 2020, Tony Plana, Brittany S. Hall, Erica Luttrell, Zsané Jhé, Bobbi Baker, Patrice Arenas, Trinity Cidel, Brandi Huzzie, Rodney Gardiner, and Janmarco Santiago joined the cast in recurring roles for the second season.

The website's critical consensus reads, "Powerful, beautiful, and like nothing else on TV, David Makes Man blends dreamy aesthetics with an empathetically crafted story to create a truly unique viewing experience.