As a senior, Murphy hit .500 with 12 home runs and 46 RBIs and was also a member of the National Honor Society.

While at Portland, Murphy had 47 hits in 172 at-bats (.273 batting average), with 17 doubles, 1 triple, 3 home runs, 25 RBI, and 11 walks.

During his time in the major leagues with the Red Sox, he played 3 games with a triple in 2 plate appearances (.500 average).

On July 31, 2007, Murphy was traded to the Texas Rangers in a package that sent relief pitcher Éric Gagné to Boston.

On April 25, 2008, the Rangers beat the Minnesota Twins 6–5 on Murphy's walk-off RBI single in the bottom of the 10th.

On August 1, 2008, Murphy capped a 3-run rally in the bottom of the 9th, hitting a walk-off 2-RBI single off B. J. Ryan as the Rangers beat the Toronto Blue Jays 9–8.

On August 7, 2008, Murphy was placed on the 15-day DL after suffering a knee injury in a collision at home plate with Iván Rodríguez of the New York Yankees.

Murphy did not play another game in the 2008 season, when swelling to his knee cut his attempts at rehab short.

On opening day against the Boston Red Sox, Murphy hit a go-ahead, pinch-hit two-run double in the eighth inning that put the Rangers up, 7–5.

Murphy made his major league pitching debut on June 4, 2013, against the Boston Red Sox when he took the mound in the eighth inning of a 17–5 rout of the Rangers in an effort to save the bullpen.

Murphy notched his first major league strikeout and was the only Rangers pitcher to record a scoreless inning that evening.

[6] He was involved in the second known occurrence in MLB history of two balls in play simultaneously when he was confused by a ball accidentally thrown from the Cincinnati Reds' bullpen and tagged out before sliding back to third base in the seventh inning of a 9–2 Indians loss at Progressive Field on August 5, 2014.