He played 14 seasons in Major League Baseball (MLB) for the Boston Red Sox, Houston Astros, Oakland Athletics, and New York Mets.

[1] In 2004, while playing for the Stanford University Cardinal baseball team, Lowrie earned Pacific-10 Conference Player of the Year honors.

At Stanford, future major league outfielders Sam Fuld, John Mayberry Jr., and Carlos Quentin were among Lowrie's teammates.

[6] Lowrie was responsible for the other Red Sox run in that game, as a sacrifice fly in the second inning allowed Bay to score from third.

[9] Lowrie's pre-season grand slam on April 4, 2009, was the first major league home run at Citi Field.

[11] On April 21, the switch-hitter underwent an ulnar styloid excision and arthroscopic ligament repair on his left wrist performed by Dr. Donald Sheridan which landed him on the 60-day disabled list.

[12] Lowrie began a minor league rehab assignment on June 21 and on July 8 the Red Sox activated him from the 60-day DL.

[18] He also made his debut as a first baseman during the 2010 season, initially as a late-innings replacement for Mike Lowell; the Red Sox planned to give him opportunities to start at first base in the future.

[20] On August 16, 2011, Lowrie started a triple play with help of Dustin Pedroia and Adrián González against the Tampa Bay Rays.

[22][23] Lowrie was about to head to an arbitration hearing, but he and the Astros agreed on a one-year, $1.15 million deal with bonuses for performance and awards on February 8, 2012.

[24] The Astros on February 4, 2013 traded Lowrie and Fernando Rodriguez to the Oakland Athletics for Chris Carter, Brad Peacock, and Max Stassi.

[29] On July 10, 2018, owning a .288 batting average with 16 home runs and 62 RBI,[30] Lowrie was named as an All-Star for the first time in his career, replacing injured Gleyber Torres on the team.

[32] Lowrie would later hit his 100th career home run against Félix Hernández of the Seattle Mariners in Oakland on August 14, 2018, in the form of a two-run homer.

[36] Lowrie did not appear in a game with the Mets in 2020 and became a free agent after the year, at which point he went forward with successful knee surgery.

[45] Following his retirement, Lowrie told the San Francisco Chronicle that he intended to spend more time with his family to include serving as an assistant coach for his daughter’s softball team.