[8] Based in Brighton, England, Pearce maintains a series of websites devoted to transhumanist topics and what he calls the "hedonistic imperative", a moral obligation to work towards the abolition of suffering in all sentient life.

[9][10] His self-published internet manifesto, The Hedonistic Imperative (1995), outlines how pharmacology, genetic engineering, nanotechnology and neurosurgery could converge to eliminate all forms of unpleasant experience from human and non-human life, replacing suffering with "information-sensitive gradients of bliss".

[14] In 1995, Pearce set up BLTC Research, a network of websites publishing texts about transhumanism and related topics in pharmacology and biopsychiatry.

[15] He published The Hedonistic Imperative that year, arguing that "[o]ur post-human successors will rewrite the vertebrate genome, redesign the global ecosystem, and abolish suffering throughout the living world.

[21] Fertility regulation could maintain herbivore populations at sustainable levels, "a more civilised and compassionate policy option than famine, predation, and disease".

[26] He is also the director of bioethics of Invincible Wellbeing[27] and is on the advisory boards of the Center on Long-Term Risk,[28] the Organisation for the Prevention of Intense Suffering[29] and since 2021 the Qualia Research Institute.