Lieutenant-Colonel Sir David Semple (6 April 1856 – 7 January 1937) was a British Army officer who founded the Pasteur Institute at Kasauli in the Indian state of Himachal Pradesh.
[1] In 1911, he developed a nerve-tissue based rabies vaccine from the brains of sheep first made rabid and then killed.
The 'Semple' vaccine however is known to have side-effects such as paralysis with high risk of other diseases, being just a crude form of churned brain-tissue.
It needs administration around the stomach in a series of very painful injections administered over a period of seven to 14 days, a course that many do not complete.
Moreover, it is not reliable and the World Health Organization (WHO) has been advocating its total disuse since 1993.