Shuster's career at MSNBC included anchoring prime time breaking news coverage of the death of Michael Jackson, the passage in Congress of historic health care reform, and the deadly earthquake in Haiti.

After MSNBC, Shuster was hired to serve as "primary substitute anchor" for Current TV's re-launch of Countdown with Keith Olbermann.

[6] Shuster and Rennert married on February 16, 2013, at the Angel Orensanz Foundation for Contemporary Art in New York City[7] and had their first child in 2013.

Shuster left CNN in 1994 to become a political reporter for the ABC affiliate KATV in Little Rock, Arkansas, covering the Whitewater scandal.

During this period, Shuster led KATV's coverage of the indictment, trial, conviction, and resignation of Arkansas Governor Jim Guy Tucker.

At KATV, Shuster won a regional Emmy Awards for investigative journalism for his reporting on a manufactured housing scandal.

In early 2003, he traveled to Qatar, where he provided coverage from the United States Central Command during Operation Iraqi Freedom for hourly live reports in prime time.

Occasionally, Shuster filled in for Chris Matthews on Hardball, including an interview of former President Jimmy Carter.

After the promotion of David Gregory to Meet the Press in December 2008, Shuster was named host of MSNBC's 6p show, 1600 Pennsylvania Avenue.

[16] In January 2012, Shuster began to host his own political talk radio show, Take Action News with David Shuster, on WPWC, a local progressive talk radio station in Washington, D.C.[17] In March of that year, the program entered syndication with WCPT in Chicago joining as the first affiliate.

[citation needed] On February 9, 2017, it was announced that Shuster had been named anchor and managing editor of the American arm of i24 News, just four days before the network began its broadcasting.

[20] In 2020, Shuster began appearing as a regular contributor to Rebel HQ, a YouTube channel that is part of The Young Turks's network.