A native of Mexico City, Villalpando started his career at the age of 14 in the theatre play El extraño jinete by Michelle de Ghelderode.
Among the plays he has starred are The two brothers by Felipe Santander, El pastelero del Rey, Alegría la lotería by Teresa Valenzuela, and Los empeños de una casa by Sor Juana Inés de la Cruz.
He won a special award (Agrupación de Periodistas Teatrales APT) for his acting in this play in 1989.
Villalpando has appeared in many international films like The Arrival, Men with Guns, Perdita Durango, Nazca, The Harvest, The Mask of Zorro, Daughter of the Puma, Nurses on the Line: The Crash of Flight 7 and American Family.
For many years he has portrayed Prof. Virolo in the little TV school Cero en Conducta and in La Escuelita VIP.