David Wesley Bole (February 15, 1856 – June 24, 1933) was a Canadian pharmacist, businessman, and politician.

Born in Watford, Warwick Township in Lambton County, Canada West, the eldest son of Irish immigrants, James and Anne Bole, Bole was educated in Watford Public School and at Woodstock College.

He worked as an editor of a Watford newspaper before studying pharmacy.

He married Isabella Lennox and moved to Regina in 1882 where he opened a drug store.

In 1885, he moved to Winnipeg and founded the Bole Drug Company Limited in 1898.