[2] In January 2001, after two and a half seasons with Reggina, he signed for Serie B fallen giants Sampdoria, but failed to make a breakthrough during his stay with the blucerchiati.
After an unimpressive season with Catania in 2002–03, Possanzini was signed by Serie B minnows AlbinoLeffe, where he quickly regained his best form and proved himself as a key player for his new club.
Still, several injuries prevented him from being actively part of the Sicilian side; he eventually played only twice with the rosanero before being sold again during the summer market, this time to Brescia as partial compensation in the deal that brought Andrea Caracciolo to Palermo.
The ban was successively suspended by the Court of Arbitration for Sport itself later in March and cancelled on 27 July 2009[3] after being proved there was no real intention to avoid the controls from Possanzini and Mannini.
He subsequently joined the coaching staff of Roberto De Zerbi, following him during his tenures at Foggia, Palermo, Benevento, Sassuolo and FC Shakhtar Donetsk.