Leonardo Semplici (born 18 July 1967) is an Italian professional football coach who is currently in charge of Serie B club Sampdoria.

His playing career mostly consisted of amateur and minor league players with Tuscan teams such as Lucchese.

In 2004 Semplici took over from Eccellenza Tuscany club Sangimignano, bringing them back to Serie D. He successively took over at Figline, bringing the Eccellenza amateurs all the way up to Lega Pro Prima Divisione in his four years at the helm of the team.

The following season proved difficult for the club, however, and after achieving just 15 points after twenty-three Serie A matches, Semplici was sacked as SPAL coach on 10 February 2020.

However, after achieving one point in the first three games of the season and following a 2–3 home loss to Genoa, Semplici was relieved from managerial duties on 14 September 2021.