A major project of the new company was organizing capitalization for replacement of every hospital facility, to conform to new seismic legislation underway in the California Legislature.

[28][29] This action was motivated in part by the since-failed merger of area teaching giants Stanford Hospital and UCSF Medical Center.

[35] In 2013, CPMC began construction of a new $2.1 billion, 274-bed hospital on the site of the former Jack Tar Hotel at Van Ness and Geary (once dubbed "the box Disneyland came in"[36]).

[37] Further, the new facility came with several patient safety focused innovations, and is the first known structure in North America to use viscous wall dampers designed to absorb strong seismic activity.

[48] On June 5, 2015, surgeons at CPMC and University of California, San Francisco successfully completed 18 surgeries in the nation's first nine-way, two-day kidney transplant chain in a single city.

[49][50][51] CPMC hosts the California Pacific Medical Center Research Institute, which conducts basic science and clinical studies into a range of topics.

In addition to these residency programs, it offers ACGME accredited fellowship positions in Cardiology, Gastroenterology, Pulmonology/Critical Care, Endocrinology, Plastic Surgery of the Hand, and Transplant Hepatology.

[56][57] In 2024, CPMC was recognized by US News and World Report as high performing in 11 common procedures and conditions, including colon and gynecologic cancer surgery, heart attack/failure, diabetes, kidney failure, stroke, and pneumonia.