He played his first three seasons of college football for the Texas Tech Red Raiders and then the California Golden Bears, before being selected by the New York Giants in the third round of the 2017 NFL draft.

In his seven seasons in the NFL, he was a member of all three franchises representing cities in New York, spending the most time with the Buffalo Bills.

While at Prosper High School, Webb guided the team to a district championship and a trip to the Texas 4A regional semifinals.

[1] Webb was ranked a 4-star prospect coming out of high school by ESPN and signed with Texas Tech University to play for the Red Raiders.

[2] Webb made his first game appearance in the contest against TCU, where he threw the game-winning touchdown to wide receiver Bradley Marquez.

Following an injury to Mayfield, Webb made his first career start in an appearance against Iowa State, which saw him pass for 415 yards and 3 touchdowns.

Additionally, the yardage broke the school freshman passing record previously held by Billy Joe Tolliver.

After Webb's poor performance against Kansas State, Mayfield returned to the starting role for the next two games against Baylor and Texas.

It was announced during the preparations for the 2013 Holiday Bowl, that Mayfield was going to be transferring from the school following a "miscommunication" and the open competition for the starting position.

[7] Both Webb and the team as a whole were named dark horse candidates for the Heisman Trophy and the national championship respectively by ESPN.

Webb still was enrolled at Texas Tech and, he was nine credit hours short of finishing his degree requirements, at the time of the announcement.

[15] California Golden Bears head coach Sonny Dykes announced on May 25, 2016, that Webb had signed a financial aid agreement and that he was enrolled officially.

[24] On November 28, 2017, head coach Ben McAdoo announced that Geno Smith would replace Eli Manning as the starting quarterback and that Webb would also see playing time before the end of the season.

Interim head coach Steve Spagnuolo admitted that it was likely Manning would remain the starter for the rest of season.

[35] He was promoted to the active roster on November 10, 2018, to serve as the backup to Josh McCown following an injury to rookie starter Sam Darnold.

On November 14, 2021, more than two years after first signing with the Bills, Webb made his NFL debut, against the Jets during garbage time.

[48] With the Giants choosing to rest starter Daniel Jones for the playoffs, Webb was promoted to the active roster for the team's Week 18 game against the Philadelphia Eagles.