He played five seasons of college football for the Syracuse Orange and one with the Illinois Fighting Illini before signing with the Giants as an undrafted free agent in 2023.

Born in Livingston, New Jersey,[1] DeVito grew up in nearby Cedar Grove and attended Don Bosco Preparatory High School.

He served mostly as the backup to starting quarterback Eric Dungey as a redshirt freshman, playing in eight games off the bench and completing 44 of 87 passes for 525 yards and four touchdowns.

[12] DeVito again played in relief of an injured Dungey on October 10 against the North Carolina Tar Heels, and he led Syracuse to a 40–37 win in double overtime, throwing for 181 yards with three touchdowns and one interception on 11-for-19 passing.

[17] In 2020, DeVito completed 48-of-96 pass attempts for 593 yards and four touchdowns through the first four games of the season before suffering a season-ending leg injury against Duke.

[19] DeVito began his redshirt senior season as Syracuse's starter, but coach Dino Babers also planned to give meaningful playing time to Garrett Shrader, a dual-threat quarterback who had transferred in from Mississippi State University.

[21][22] The following week, Syracuse lost the home opener against the Rutgers Scarlet Knights 17–7, with DeVito completing 15 of 25 passing attempts for 149 yards and one interception, five sacks, and one fumble, in split time with Shrader.

[25][26] DeVito was defiant in a press conference before the Albany game, responding, "I've done exactly what I've needed to" when asked if he thought he had earned the starting spot, while also describing how defenses had caught onto the run-pass option (RPO) offense Syracuse was running, and thus it had become a more difficult system to run in the years since Jimmy Garoppolo ran the offense for Babers at Eastern Illinois University to great success.

[36][37] In Week 8, DeVito made his NFL debut on October 29, 2023, against the New York Jets, after an injury to second-string quarterback Tyrod Taylor.

[39] In Week 9, he entered the game against the Las Vegas Raiders in relief of an injured Daniel Jones and threw for 175 yards and his first NFL passing touchdown, but also had two interceptions.

[46][47] As the season progressed, DeVito quickly became a fan favorite, both for going from an undrafted third string rookie quarterback to leading an underachieving Giants team to some surprising success, and also for being openly proud of his Italian heritage.

[57] DeVito's rise to fame led to several advertising deals including a Super Bowl commercial, allowing him to move out before the 2024 season.