In 2006, Moore was hired by the Kansas City Royals to fill a vacancy in their general manager position, replacing Allard Baird.

[5] He played baseball at Garden City Community College before graduating from George Mason University in 1989, with an undergraduate degree in Physical Education and Health.

[6] Moore received a master's degree in Athletic Administration from George Mason in 1992,[6] and served as an assistant baseball coach at the university from 1990 to 1994.

[11] The Kansas City Royals hired Moore as general manager on June 8, 2006,[10] replacing Allard Baird.

[13] In December 2010, Moore traded Zack Greinke, who had previously won the Cy Young Award for the Royals, and Yuniesky Betancourt to the Milwaukee Brewers in exchange for a group of players including Alcides Escobar and Lorenzo Cain.

[19] In June 2018, Moore generated backlash with comments he made about convicted child molester and Oregon State University pitching prospect Luke Heimlich, saying, "I think the player has earned the opportunity to play professional baseball.

"[20] In late 2019, Royals owner David Glass sold the team to businessman John Sherman, who retained Moore as general manager.

Moore is also the author of the book "More Than a Season", which describes his part in the Royals' success from a losing team to the 2014 World Series.