[10] The program of studies offered at DePaul Catholic High School seeks to equip college-bound students with a foundation for the pursuit of academic excellence while emphasizing a curriculum tailored to individual differences.

The DePaul Spartans[6] competes in the Big North Conference, which consists of public and private high schools in Bergen and Passaic counties, and was established following a reorganization of sports leagues in Northern New Jersey by the New Jersey State Interscholastic Athletic Association.

[17] The football team was awarded the sectional championship by the New Jersey State Interscholastic Athletic Association in 1962 and 1972 (as co-champion).

[20][21] The 1992 team won the Parochial B North title with a 28-21 win against six-time defending champion Pope John XXIII Regional High School, which came into the playoff finals unbeaten in its previous 24 games.

[23] In 2017, facing a third-seeded Saint Joseph Regional High School team that had won the previous 13 games between the two teams, top-seeded DePaul won the Non-Public Group III state sectional championship by a score of 7–3 in the tournament title game played at Kean University's Alumni Stadium.

[24][25] The team won the Non-Public Group III in 2019, the program's fifth title in a seven-year span, with a 27-25 win in the finals against Mater Dei High School.

[31] The 1989 team won the Parochial B state title by 601⁄2 to 37 ahead of second-place finisher and returning champion Immaculate Conception High School of Montclair.