The university's teams play in the NCAA Division III and currently belong to the North Coast Athletic Conference.

In the 2009–10 season, Stevens led his team to the national championship game before eventually losing to Duke.

Future U.S. House Representative Lee H. Hamilton lettered in three seasons for the DePauw men's basketball team (in 1949–50, 1950–51, and 1951–52).

DePauw's baseball team has reached the NCAA Division III tournament six times in their history, and won a school-record 35 games in 2008.

[10] Prominent baseball alumni include former MLB Commissioner Ford Frick[11] and long-time NCAA football coach Dick Tomey.

[14] DePauw's women's field hockey team have made two NCAA tournament appearances in their history and won the SCAC championship in 2007.

In their history, the women's team have national runners-up twice, been in the top four seven times, and made nine consecutive NCAA appearances.

[16] The men's golf team have made 21 NCAA Division III appearances and have been either SCAC champions or runners-up four times.

[18] Lacrosse was added as a men's and women's varsity sport at DePauw University effective with the 2012–13 academic year.