[2] The first De La Salle School in the Philippines, De La Salle College was opened on June 16, 1911, on Calle Nozaleda in Paco, Manila, at the request of the Archbishop of Manila, Jeremiah James Harty to the Brothers of the Christian Schools.

[4] The school is located in Muntinlupa's Ayala Alabang Village and was made possible through a joint donation of part of the campus's eleven hectare lot donated by the Ayala Corporation and the Madrigal Family, with the rest of the lot acquired through financing provided by the Filipinas Life Assurance Company.

[2] De La Salle Zobel opened in June 1978 with an initial offering of Prep to Grade Six Levels.

Raymond Bronowicz FSC, then the Vice-President for Administration of De La Salle University, was appointed as Zobel's first director.

The Grade School curriculum is structured into six learning areas: Mathematics, Science, Language, Reading, Filipino, and MAKABAYAN, the component subjects of which are Christian Living, Social Studies, Computer Science, Music and Art, Physical Education, and Home Economics and Livelihood Education.

The High School curriculum, on the other hand, is composed of ten subject areas, which are: Christian Living, English, Araling Panlipunan, Filipino, Science, Math, Music and Art, Physical Education, and Technology and Home Economics.

[5][6][7][8] With the thrust of supporting the holistic development of students, Zobel further developed the intellect and artistry of its students with the establishment of the Angelo King Center for the Performing Arts in 2000, which is housed in the school's Center for the Performing Arts Building.

A marker bearing such recognition was unveiled at the lobby of the Center by then CCP President Nestor Jardin, DLSZ's Br.

Jaime Dalumpines, FSC, DSLZ-DIPS Director Amanda Boyles, and the head of the Center, Albert Madrigal.

In 2009, Zobel's varsity team, the De La Salle Junior Archers, is De La Salle University-Manila's junior representative to the University Athletic Association of the Philippines while its women's team, the Lady Junior Archers, is De La Salle-College of Saint Benilde's representative to the Women's National Collegiate Athletic Association.

[13] The campus is situated on an irregularly shaped lot located at the heart of the Ayala Alabang Village.

In the master plan, the main objective was the creation of a unified learning environment, with the school grounds having a countryside atmosphere.

At present, the campus is composed of a number of structures which have been necessitated by the burgeoning school population.

The basement level, which was formerly a canteen-cum-multi-purpose hall was turned into the school's Learning Resource Center in 1992.

The facade was where the two flagpoles and the St. La Salle statue were formerly located until 2011 when the former was moved to the St. Mutien Marie Building, and the latter near the Our Lady of the Star (OLSTAR) chapel.

Atop the iNook is a mini courtyard (built in 2005 as well) used for some school activities, which was renovated in 2014.

Beside the Main Building is the newly built, state-of-the-art Our Lady of the Star Chapel where regular masses are held.

In 2005, a model home was built by the back of the original building to house the Cooking and Sewing classes.

The St. Flavius Hall houses the school's main canteen was built in 1991 with the initial food service management being handled by The Aristocrat Restaurant of Engracia Reyes.

The immediate past handler of the canteen management was Race Foods, Inc. and at present, it is handled by ZaiDe.

Flavius Leo FSC, one of the sixteen Christian Brothers who were massacred in the Most Blessed Sacrament Chapel of De La Salle University on Taft Avenue, Manila during the Battle for the Liberation of Manila in World War II.

J. Benedict FSC(1927–2004), the only living American Christian Brother who has been serving in the Philippines for more than fifty years.

On the first floor is an outdoor playground, the Multipurpose Hall, Medical Clinic Annex, Classrooms for Grades 1A to 1H and the interdisciplinary Botanical Garden.

In 2000, this building was completed and would be named after DLSU alumnus Angelo King, who had contributed a significant amount to help finish its construction.

[9] The Angelo King Center has a Php150 million theater equipped with state-of-the-art lights and sound facilities, which were imported form Germany.

The theater has a seating capacity of 1,052 with balcony and orchestra sections, a two-level lobby, an orchestra pit, four air-conditioned dressing rooms, costume cabinets, a docking area, sixteen fly battens, two motorized curtain systems (vertical and horizontal), and comfort rooms.

[16] The television program Digital LG Quiz game show was hosted by 2 Lasallians - LSGH alumnus David Celdran and DLSU alumnae Bianca Araneta who taped several episodes at the King Center Theater for several years.

Ceci Hojilla, FSC Center for Lasallian Formation has its own choir loft and can accommodate 460 people.

In 2005, the pool house was rebuilt and is now a multi-level building with locker & shower rooms at the ground floor and spectator-stands at the upper level.

Enrique Zobel was then the President of the Ayala Corporation when De La Salle-Zobel was established.