De Maisonneuve was created as a single street in 1966, following the construction of the Montreal Metro.

Institutions already located along the street such as the Université du Québec à Montréal, Place des Arts and Concordia University have built new buildings.

Other institutions have also built new buildings on the street such as the Grande Bibliothèque, the Cinémathèque québécoise and the Salle Pierre-Mercure.

Other notable buildings include the Grande Bibliothèque, Université du Québec à Montréal, Place des Arts, Les Cours Mont-Royal, both of Concordia University's campuses (Sir George Williams and Loyola) and Montreal Forum.

The Green line of the Montreal Metro runs under this street in between Papineau and Atwater.