[3] During the back half of the 1890s, plans were made for a new high school at the corner of Chicago Street and Broadway.

[3] After spending the rest of the term at the local German Benevolent Society Hall, the school located at Chicago and Broadway opened in fall 1900.

In 2005, the school received a cease-and-desist order on the grounds that its mascot was copyrighted material of Illinois State University.

The team, which has been in existence since 2006, offers students the opportunity to gain hands-on knowledge in STEM fields.

De Pere High School is a member of the Fox River Classic Conference, and its athletic teams are nicknamed the Redbirds.

[18] The school contributes to the ten-school cooperative Bay Area Ice Bears girls hockey team, which plays in the Eastern Shores Conference.

[24] In 2020, the school hosted a show choir competition, "Destination De Pere: Let's Jam!