In Switzerland they soon became politically and socio-economically active holding a variety of public offices.

[citation needed] Horace-Bénédict de Saussure (1740 – 1799), an 18th century naturalist, was probably the most notable, his portrait was on the 20 Swiss Francs bill series which were in circulation from 1979 to 1995.

A 21st century descendant of this branch, is Jacques de Saussure, who was a part-owner in private bank Pictet Group and current[when?]

[5] Henri de Saussure (anglicized to Henry de Saussure, d. 1761), a scion of the Lausanne branch of the family, emigrated from Vaud in the Old Swiss Confederacy settling near Charleston, South Carolina.

Daniel was the father of Henry William de Saussure, d. 1839, a notable jurist in the early days of the American republic and chancellor.