De Soto Avenue is a north–south arterial road that runs for 7.5 miles (12.1 km) between US 101 and SR 118 in the San Fernando Valley in Los Angeles, California.

Several of the San Fernando Valley's north–south streets were originally named after historic explorers, including De Soto, Balboa, Alvarado, Cabrillo, Cortez, and Diaz, but De Soto Avenue and Balboa Boulevard are the only street names that remain.

[1] De Soto travels north–south between US 101 and SR 118, across almost the entire San Fernando Valley.

From north to south, De Soto travels from Chatsworth, through Canoga Park and Winnetka (the street marks the border between these two neighborhoods), and into Woodland Hills.

[citation needed] Metro Local Line 244 runs along De Soto Avenue between Devonshire Street and Ventura Boulevard.