Dead Man's Handle is the title of a 1985 action-adventure and spy novel written by English writer Peter O'Donnell.

It was the eleventh and final full-length novel chronicling the adventures of O'Donnell's comic strip creation, Modesty Blaise.

Dr. Pilgrim sends Sibyl and Kazim, his two top assassins, to England to capture Willie Garvin and bring him to Kalivari under heavy sedation.

In other words, Willie is now programmed to kill Modesty on sight, at which point he will regain his memory, and presumably go insane when he realises what he has done.

The story does not end here, and soon Dr. Pilgrim's obsession with interesting scenarios goes horribly wrong (for him) when Sibyl and Kazim are killed in gladiator-style duels and Dr. Janos Tyl is felled by a heavy round shield thrown frisbee-style by Willie.