The premise of the game centers around a mysterious character known as Edward Blackgate, and the lost souls interred in his private cemetery, "Everlasting Life".

Miss Jessie Bodeen is characterized as a New Orleans Voodoo queen, who acts as a healer for the local African Americans working as servants in the city.

Now a resident at "Everlasting Life", Jessie tells the story of her downfall when she accepts a commission from Delphine LaLaurie, a character based on her real-life counterpart.

However, after three months and the end of the social season in New Orleans, Delphine LaLaurie reneged on their deal, despite Jessie Bodeen upholding her part of the bargain.

Furious about having been lied to, Jessie Bodeen makes up her mind to seek revenge on Delphine LaLaurie by invoking the Loa, particularly Damballa, to avenge her.