[10] On November 18, Wade made his NBA debut against the New York Knicks, he went scoreless but logged one steal in eight minutes of action.

In the G League, Wade started in 29 of 30 games, averaging 14.2 points, 7.6 rebounds, 2.3 assists and 1.4 blocks in 31.1 minutes while shooting 46.1% from the field and 39.9% from 3-point range.

[14] On February 23, 2021, Wade made his first NBA career start, logging five points, two rebounds and two assists across 20 minutes in a 112–111 win over the Atlanta Hawks.

[17][18] On March 3, Wade scored a then-career-high 17 points, knocking down five 3-pointers to go along with six rebounds, two assists and one steal across 31 minutes of play in a 114–111 loss to the Indiana Pacers.

[24][25][26] After Lauri Markkanen entered the NBA's COVID-19 health and safety protocols, Wade became the starter at the small forward position.

[31][32] With Markkanen being sidelined due to a sprained ankle he sustained in a game against the Oklahoma City Thunder on January 22, 2022, Wade returned to the starting lineup.

[38] On October 30, 2022, Wade scored a career high of 22 points shooting 6-of-8 from three versus the New York Knicks.