Apart from LuPone, Kathryn Hahn reprises her roles as Harkness from the WandaVision miniseries, with Joe Locke, Sasheer Zamata, Ali Ahn, Debra Jo Rupp, and Aubrey Plaza also starring.

Calderu explains the reason behind her frequent chaotic utterances and memory lapses—since childhood, she has been experiencing life out of chronological order due to her mind shifting through different points in time.

[2] By October 2021, a "dark comedy" spin-off from WandaVision centered on Kathryn Hahn as Agatha was in early development for Disney+ from Marvel Studios,[3] with Schaeffer returning as head writer and executive producer.

[9] According to Schaeffer, it was an early idea to create an episode of Agatha All Along which would be told non-linearly, drawing inspiration from various films and television series such as Memento (2000), Lost (2004–2010), Arrival (2016), and Everything Everywhere All at Once (2022).

[11] The episode stars Kathryn Hahn as Agatha Harkness, Joe Locke as Billy Maximoff, Patti LuPone as Lilia Calderu, Sasheer Zamata as Jennifer Kale, Aubrey Plaza as Rio Vidal, and Ali Ahn as Alice Wu-Gulliver.

[12] The Salem Seven are played by actresses Okwui Okpokwasili, Chau Naumova, Bethany Curry, Athena Perample, Alicia Vela-Bailey, Britta Grant, and Marina Mazepa.

[12] While Agatha All Along creator and showrunner Jac Schaeffer was always set to helm "Seekest Thou the Road" and "Circle Sewn with Fate / Unlock Thy Hidden Gate," the first two episodes of the series,[11] the show was already well into pre-production, when a scheduling issue opened up the director's chair for "Death's Hand in Mine.

[10] Schaeffer, who called "Death's Hand in Mine" a "nearly impossible episode to put together,"[10] later noted that associate producer Ishi Metkar served as her "second brain" on set.

[12]: 29:55 On October 25, 2024, Disney revealed that "Death's Hand in Mine" drove 4.2 million views globally after just one day of streaming, up 35% from the performance of the miniseries' premiere episode "Seekest Thou the Road.

"[19] Whip Media, which tracks viewership data for the more than 25 million worldwide users of its TV Time app, reported Agatha All Along as the most-streamed original series in the U.S. for the week of the episode's premiere.

The site's critical consensus reads, "Agatha All Along finds its magical witching hour in a spellbinding episode that casts Patti LuPone as its emotionally striking linchpin.

Bridging past, present, and future together to reckon with the inevitability of time, "Death's Hand In Mine" is lucky enough to grant Patti LuPone the stage."

[23] IGN's Eric Goldman rated the episode 8 out of 10 and called it a "fitting send off for Lilia, who got a great spotlight here that allowed Patti LuPone to shine."

He felt that "Death's Hand in Mine" did a "much better job than the fourth [episode "If I Can't Reach You / Let My Song Teach You"] did with Alice, during her trial, of investing us in Lilia on a deeper level.

"[25] The Daily Beast's Kevin Fallon found that the episode was "superb" and described it as "a tour de force for Patti LuPone," calling her portrayal the "most impressive" and "best performance we'd get in a MCU television series.

"[26] Alan Sepinwall, writing for Rolling Stone found that "Death's Hand in Mine" was "both a terrific showcase for the great star of stage and screen and an excellent example of using sci-fi/fantasy to tell a nonlinear story.

"[27] Vulture's Caroline Framke called the episode an "incredibly ambitious chapter [that] manages to both incorporate that and unravel a completely different but no less personal story spanning centuries of fear and hurt."

LuPone grabs the opportunity to highlight Lilia's with both hands here [...] and she never so much as sings a note—an unexpected move from an otherwise very musical show, but one that pays off, because her acting is just as nuanced and bold as her voice.