[5] A 2011 meta-analysis in the Journal of the American Medical Association found that each additional hour of sexual activity per week resulted in an increased risk of 2–3 myocardial infarctions and one sudden cardiac death [SCD] per 10,000 person-years.
[7][8] A 2011 meta-analysis published in Journal of Sexual Medicine found that men who were unfaithful were significantly more likely than those who were faithful to experience severe or fatal cardiac events during sex.
[15] One treatment for erectile dysfunction is cGMP-specific phosphodiesterase type 5 inhibitors, which enable patients to resume having sex despite having a cardiac condition, by lowering blood pressure.
[15] These drugs, including sildenafil, inhibit the action of the phosphodiesterase, allowing for a higher concentration of cyclic GMP in the penis when it is physically stimulated.
[15] The phosphodiesterase can act as a potentiator for other drugs which lower blood pressure and which could be used to treat heart conditions, and so may be contraindicated to prevent negative health consequences.