[4][5] Descended from one of the Fisher brothers, owners of Fisher Body,[6] from 1919 a part of General Motors, she has served as president[7] of the General Motors Foundation and as executive director of Global Community Relations and Government Relations at GM.

[12] When Carl Levin announced his retirement from the U.S. Senate at the end of his term in 2015, Dingell indicated that she was interested in running for his seat.

[13] When former Michigan Governor Jennifer Granholm declined to run for the seat, a Politico writer declared Dingell to be one of the front-runners for the Democratic nomination, alongside Representative Gary Peters.

His father, John Dingell Sr., held Michigan's 12th district for 22 years before his son won it.

In 2018, Dingell introduced a law that would give the Consumer Product Safety Commission the authority to recall defective firearms.

[21] In April 2021, Dingell introduced the Recovering America's Wildlife Act of 2021, a bill that would provide funding for conserving and protecting endangered and threatened species, strategies to do so, and wildlife-related recreational activities.

[24][25] After Dingell voted to impeach President Donald Trump, Trump attacked Dingell during a campaign rally in Battle Creek, musing that her late husband, might be in hell, saying of him, "Maybe he's looking up, I don't know, I don't know, maybe, maybe.

"[26] She was attending a bipartisan Problem Solvers Caucus gathering when she was told of Trump's remarks.

According to Haberman, "Dingell couldn't shake the idea that his voice sounded like that of the forty-fifth president.