Castillo has explored various artistic media, including video, photography, sculpture, and performance art, disciplines that she intertwines to create complex works that make political statements.
Art critic Irina Troconis has identified the military figure Castillo so often singles out as the subject of her criticism as the caudillo: "Though the head’s identity was never explicitly revealed, there was no mystery regarding what it represented; the frown, the beard, and the military epaulettes gave it the authoritative air of the caudillo, and brought to mind the boundless power historically embedded in that figure and its many visual iterations in the urban and political landscape of Latin America.
[9] Art historian Sara Garzón has compared Castillo's "iconoclastic" pieces that attack effigies of Bolívar to social protest movements that topple monuments; the artist trivializes the heroic image while performing civil disobedience.
[10] Her 2018 exhibition, "Parricidios," at El Museo de Arte Carrillo Gil (MACG) in Mexico City featured Las Dictadoras (2017), a sculptural configuration of five female bodies that parodied the five iconic male leaders Mao ZeDong, Joseph Stalin, Karl Marx, Vladimir Lenin and Fidel Castro.
[11] Castillo was forced to leave Venezuela, at one point going into hiding, because its totalitarian regime censored her artwork and its political critiques.