Prior to her acting career, she originally aspired to become a ballerina and trained at Elmhurst Ballet School in Surrey.

Makepeace also landed a reoccurring role as a student nurse on the hit BBC television series, Angels.

She then appeared as Princess Helena of the United Kingdom in three episodes of the Emmy and BAFTA winning ATV costume drama series, Edward the Seventh (1975).

Makepeace made her voice acting debut in 1993 for the English dub of the anime The Heroic Legend of Arislan as Elam.

She would also provide voices for the English dub of Rumic World: Fire Tripper, where she provided the voice of Suzuko (credited as Cynthia Meade), and the English dub of Seiden RG Vega, which would ultimately be her final known credit.