D-Medikus SE was founded in 2005, consisting of medical students of the University of Debrecen.

In the Nemzeti Bajnokság II, the team finished in the middle field in the first year, then fell back to the county championship.

The team that won the silver medal in 2012 returned to the Nemzeti Bajnokság II championship.

In the 2016/2017 season, the team took first place in the North-Eastern group of the Nemzeti Bajnokság II adult, so it was able to continue the 2017/2018 season in the Nemzeti Bajnokság I/B.

They failed to stay in the 2018/2019 season, so the team is fighting again in Nemzeti Bajnokság II.