The following years, Pfeiffer had starring roles in a number of films, mostly critically panned, include Vamp (1986), The Allnighter (1987) and The Horror Show (1989).
[1] She had secondary roles in films Frankie and Johnny (1991) and Up Close & Personal (1996) starring her sister, and well as Falling Down (1993) and My Family (1995).
Her other television credits include guest-starring roles on Hotel, Murder, She Wrote, Seinfeld, Wings, Ellen, and Friends.
Apart from a couple of brief appearances, Pfeiffer took a long break from acting in 2010, almost ten years, battling alcohol addiction.
[7] In 2020, Pfeiffer returned to acting, playing the role of Denise Brisbane in the ABC crime drama series Big Sky, created by her brother-in-law David E.