[2] Mekelakeya is historically the second most successful club in Ethiopian football history with 11 top division titles, with the most recent coming in 1989.

They were knocked out of the tournament by Cameroonian side Yong Sports Academy 2–1 on aggregate in the preliminary round.

[4] On April 30, 2018, the club was involved in a match where they were awarded a goal that their opponents, Welwalo Adigrat University, disputed.

[5] In April 2021, the club was promoted back into the Ethiopian Premier League after a successful campaign in the second division.

Note: Flags indicate national team as defined under FIFA eligibility rules; some limited exceptions apply.