Branch was named the Most Valuable Player of Super Bowl XXXIX on February 6, 2005, after tying former San Francisco 49ers wide receiver Jerry Rice and former Cincinnati Bengals tight end Dan Ross for the Super Bowl reception record with 11 catches for 133 yards.

[4] Branch played for the Seattle Seahawks from 2006 to 2010 before a second stint with the Patriots for the next two seasons, which included an appearance in Super Bowl XLVI.

After graduating from high school, Branch attended Jones County Junior College in Ellisville, Mississippi, where he played football for two seasons and was also a teammate of Javon Walker.

He was named an All-Conference USA first-team selection in addition to being voted the Cardinals' Most Valuable Player and Outstanding Offensive Performer.

The Cardinals finished the 2001 season with a record of 11–2, won the Conference USA Football Championship again and went to the 2001 Liberty Bowl where Branch had a 34-yard touchdown reception in their 28–10 win against BYU.

In Week 4 against the San Diego Chargers, Branch caught 13 passes, the second-highest single-game total by a rookie in NFL history.

In the Patriots' victory in Super Bowl XXXVIII over the Carolina Panthers, Branch caught 10 passes for 143 yards and a touchdown.

His 17-yard catch on the final drive with seconds remaining set-up Adam Vinatieri's game-winning 41-yard field goal.

Following the 2005 season, Branch entered the final year of his five-year rookie contract signed in 2002, with his base salary scheduled to be $1.045 million in 2006.

[9] It was the last formal contract discussion between the two sides, leading Branch to hold out of the team's mandatory June minicamp, training camp, and the preseason.

[9] On August 25, 2006, the Patriots announced that Branch was given permission to seek a trade and negotiate a contract with other teams through September 1, 2006.

Branch had 343 yards for the Seahawks in the first five games (all starts) of the 2007 season, before suffering a foot sprain and not returning until Week 11.

Branch began his final season in Seattle in 2010 by starting three of the team's first four games, catching 13 passes for 112 yards and one touchdown.

Two weeks later, against the Chicago Bears, Branch caught a 59-yard touchdown pass from Brady at the end of the first half of a Patriots victory.

[17] On November 17, 2012, he was waived to make room for practice squad receiver Greg Salas, but he again re-signed on December 11 due to injuries to Julian Edelman and Donté Stallworth.

Deiondre contracted meningitis shortly after birth and has been left with irreversible brain damage that prevents him from walking or talking.

[27] Branch was the director of player development at Louisville before the departure of Scott Satterfield at the end of the 2022 regular season to accept a different position required an interim coach.