Del Reyes de Guzman (born January 9, 1963) is a Filipino politician who served as the 11th Mayor of Marikina from 2010 to 2016.

During the election, his campaign manager Mila Andrade was assassinated on May 3, 2007 by a man riding a motorcycle[1] In 2010, de Guzman opted to run for mayor to succeed term-limited mayor Marides Fernando, with physician and councilor Jose Fabian Cadiz being his running mate.

De Guzman defeated then-outgoing vice mayor Marion Andres and Alfredo Cheng with 66.34% of the vote, along with his running mate who was elected vice mayor with 57.91% of the vote.

In 2016, de Guzman was defeated for in his bid for a third and final term, with Marcelino Teodoro being elected as his successor.

In 2022, de Guzman ran for representative of Marikina's 2nd district under Aksyon Demokratiko, but lost to incumbent Stella Quimbo.