They won their first ever NCAA Tournament game in 2012, beating Little Rock 73–42 before losing in the ensuing round to Kansas 70–64.

They made the regional semifinals in the 2013 NCAA Division I women's basketball tournament after beating West Virginia 66–53 and North Carolina 78–69 before losing to Kentucky 69–62.

Elena Delle Donne played for the Blue Hens from 2009 to 2013, scoring 3,039 points, good for 9th in the all-time list.

[4] As of the end of the 2020–21 season, the Fightin' Blue Hens have an all-time record of 820–552.

The 2006 Women's National Invitation Tournament expanded from 32 to 40 teams, adding an additional round of games.