The first intercollegiate season began in 1921, playing their first game against Swarthmore College.

Drexel has received three bids to the NCAA Division I tournament, occurring in 2009, 2021, and 2024.

Drexel's women's basketball team won their first national title in 2013, winning the NIT Tournament.

On February 22, 2007, Drexel defeated Northeastern 98–90 in an NCAA Division I record five overtimes.

The Dragons have appeared in the Women's National Invitation Tournament (WNIT) eleven times, winning it in 2013.