In 2015, the southern terminus was cut back to its current location, removing the concurrency with DE 2.

Past this junction, DE 41 continues northwest as a two-lane undivided highway, crossing Hyde Run again, and heads towards Hockessin, with stretches of divided highway around the intersections with Millcreek Road/Hercules Road and McKennans Church Road/Loveville Road.

DE 41 turns to the west-northwest and passes to the northeast of the Sanford School before it crosses Brackenville Road.

The route enters business areas and becomes a three-lane divided highway, with the southbound direction gaining a truck lane as it descends a hill.

The median turns into a center left-turn lane as the road runs past more developments, passing northeast of a park and ride lot located at a bank, and crosses the Wilmington and Western Railroad again at-grade.

The route passes north of a park and ride lot at the Hockessin Memorial Hall before it comes to the Yorklyn Road intersection, where the southbound direction narrows to one lane.

DE 41 reaches the Pennsylvania state line, where Gap Newport Pike continues northwest as PA 41.

[3][4] DE 41 serves as part of the main route connecting Wilmington, Delaware, to Lancaster, Pennsylvania, and sees heavy truck traffic.

[12] Plans were underway in 1927 to replace the outdated swing bridge over the Christina River in Newport.

[15] In 1927, plans were made to replace the grade crossing at the Pennsylvania Railroad line (now Amtrak's Northeast Corridor) in Newport with an underpass under the tracks.

[17] In 1954, plans were made to replace the intersection with US 13/US 40/US 202 in Basin Corner with a modified cloverleaf interchange in an effort to reduce traffic congestion.

These improvements constructed a bypass of Hockessin and added truck lanes on steep grades.