The southernmost section of the route in the U.S. state of Delaware passes through northern New Castle County.

It runs from its southern terminus at an interchange with US 13/US 40 near the Wilmington Airport north to the Pennsylvania state line in Brandywine Hundred.

US 202 is a multilane divided highway the entire length across Delaware, with the section concurrent with I-95 a freeway.

US 202 begins at a partial cloverleaf interchange with US 13/US 40 east of the Wilmington Airport, with the road continuing south toward the city of New Castle as DE 141.

The road passes between the Delaware Air National Guard's New Castle Air National Guard Base to the west and commercial establishments to the east, coming to a junction with the northern terminus of DE 37.

The freeway comes to bridges over Norfolk Southern's Shellpot Secondary and Little Mill Creek as it continues through more wetlands west of the Russell W. Peterson Urban Wildlife Refuge, with Amtrak's Northeast Corridor running parallel a short distance to the northwest.

I-95/US 202 continues through residential areas to the west of downtown Wilmington and passes over DE 9, with a southbound exit.

Farther northeast, the freeway heads into an alignment below street level and comes to an interchange with DE 52.

[4][5] Upon splitting from I-95, US 202 heads north on the six-lane divided Concord Pike into the Brandywine Hundred area, running between Alapocas Run State Park to the west and the Rock Manor Golf Course to the east and passing over East Park Drive before coming to an interchange with the northern terminus of DE 141 and the southern terminus of DE 261 in Blue Ball that also provides access to the Augustine Cut-off.

The route passes between AstraZeneca's North American headquarters to the west and businesses to the east.

[6] The Wilmington and Great Valley Turnpike Company was chartered on January 23, 1811 to build a turnpike running north from Wilmington along the Concord road, continuing to West Chester and Great Valley in Pennsylvania.

[11] By 1924, the Concord Pike between Blue Ball and Talleyville was a state highway, with the remainder remaining a county road.

Also at this time, US 202 was realigned in Wilmington to head southwest from Concord Avenue onto Baynard Boulevard, splitting into a one-way pair following Washington Street southbound and West Street northbound as it passed through downtown Wilmington.

[16] In 1953, the portion of US 202 along the Concord Pike between the Wilmington border and Murphy Road was widened into a four-lane divided highway.

[17] In September 1953, construction began to widen the portion of US 202 between Murphy Road and Talleyville into a four-lane divided highway.

On August 7, 2015, a dedication ceremony to mark the completion of the project was held, with Governor Jack Markell, Senator Tom Carper, and DelDOT secretary Jennifer Cohan in attendance.

[35] On September 25, 2017, the section of US 202 along Concord Pike between I-95 and the Pennsylvania state line was dedicated as the Gold Star Highway in honor of families of military members who died in service, with Governor John Carney and DelDOT secretary Cohan in attendance at a dedication ceremony.