The route passes through rural areas of western Kent County as well as the town of Hartly.

The road passes through a mix of woodland and farmland before reaching the town of Hartly.

In Hartly, the route intersects DE 11, where it becomes Main Street, and passes by homes along with some commercial establishments, crossing an abandoned railroad line.

[3][4] DE 44 has an annual average daily traffic count ranging from a high of 4,188 vehicles at the eastern terminus at DE 8 to a low of 1,565 vehicles at the western border of Hartly.

[1] The entire length of DE 44 is part of the National Highway System.