The route passes through rural areas of northern Kent County as well as the towns of Clayton and Smyrna.

DE 6 begins at the Maryland border, where the road continues west into that state as MD 291.

From the state line, the route heads east on two-lane undivided Millington Road, passing through the Blackiston Wildlife Area.

The route continues east through more agricultural areas and reaches a junction with DE 15, at which point residential development near the road increases.

The two routes pass a mix of homes and businesses before gaining a center left-turn lane past the Main Street junction and entering a commercial area in the northern part of Smyrna as East Glenwood Avenue.

The route intersects DE 9 before curving northeast into marshland within the Woodland Beach Wildlife Area.

Past the eastern terminus, the road continues as Beach Avenue for one block to a parking lot adjacent to the Delaware Bay.

[10] When Delaware created its state highway system by 1936, DE 6 was routed between the Maryland border west of Blackiston and Woodland Beach, following its current alignment to Smyrna, passing through Smyrna on Commerce Street, and continuing east on its current alignment to Woodland Beach.