From Stanton to the Pennsylvania border, DE 7 heads northwest through suburban areas, passing through Pike Creek.

From the southern terminus, the route heads north on four-lane divided South Dupont Highway.

The road runs between farmland to the west and warehouses to the east, narrowing to two lanes and crossing Norfolk Southern's Reybold Industrial Track railroad line at-grade before passing under the US 13/DE 1 freeway without an interchange.

The road crosses Norfolk Southern's New Castle Secondary railroad line at-grade and heads into Bear.

[3][4] After this intersection, the route becomes Bear-Christiana Road and passes through suburban residential development with some farm fields.

Following this, DE 7 becomes East Main Street and narrows into a two-lane undivided road, heading through woods and curving to the northwest as it crosses the Christina River.

At this point DE 4 turns north for a concurrency with DE 7, running through wooded areas with nearby development, including the Hale-Byrnes House, and passing over Amtrak's Northeast Corridor railroad line and the White Clay Creek and Mill Creek near their confluence.

The road heads to the east of Delaware Park, which consists of a Thoroughbred horse racetrack, casino, and golf course.

At this point, the two routes continue into a commercial area and split into the one-way pair of Mitch Road eastbound and Main Street westbound.

The road runs through suburban residential neighborhoods, coming to a bridge over CSX's Philadelphia Subdivision railroad line.

Past this junction, DE 7 heads into residential and commercial areas and turns into a four-lane undivided road.

The road curves west, crossing Mill Creek and passing to the north of Carousel Park, before turning northwest again and running to the northeast of a park and ride lot located at a church and southwest of Goldey–Beacom College, a private non-profit college.

DE 7 turns into a two-lane divided highway as it passes southwest of the Lantana Square shopping center, where a park and pool lot is located, and intersects Valley Road.

Past this, the route becomes a two-lane undivided road that runs through fields and residential areas, briefly gaining a northbound truck lane as it climbs a hill.

DE 7 reaches its northern terminus at the Pennsylvania border, where Limestone Road continues north into that state as SR 3013, an unsigned quadrant route that heads to an interchange with PA 41.

[10] DE 7 was designated to run from US 13 south of Red Lion north to the Pennsylvania border by 1936, following its present alignment.

The route was shifted west to a new alignment passing over the Amtrak tracks and the White Clay Creek.

[19] The DE 1 freeway was extended from US 13 in Tybouts Corner to St. Georges in December 1995, in which it incorporated a portion of the existing US 13 near Red Lion.