It is located on the Groningen–Delfzijl railway after Delfzijl West as the terminus for passengers.

The railway line continues further east, but only for freight trains.

The station building was completed in 1883 and train services started on 15 June 1884.

[1] Train services have been provided by Maatschappij tot Exploitatie van Staatsspoorwegen (1884–1937), Nederlandse Spoorwegen (1938–2000), and NoordNed (2000–2005).

There are seven regional bus connections at the station in Delfzijl with the following destinations:[4]