Hoogezand-Sappemeer (Dutch pronunciation: [ɦoːɣəˌzɑnt sɑpəˈmeːr] ⓘ; abbreviation: Hgz) is an unstaffed railway station in Hoogezand in the Netherlands.

It is located on the Harlingen–Nieuweschans railway between Martenshoek and Sappemeer Oost in the province of Groningen.

Train services started in 1868 and the current station building was completed in 1989.

Among the direct destinations are Groningen to the west, Veendam to the southeast, and Winschoten, Bad Nieuweschans, and Leer (Germany) to the east.

The railway station is located at the Stationsweg in the municipality of Midden-Groningen in the south of the province of Groningen in the northeast of the Netherlands.