[4] S. Claiborne "Clay" Johnston was named as the medical school's inaugural dean in January 2014.

[5] On September 1, 2021, Johnston stepped down from his position and George Macones was named interim dean.

They sit on existing University property at the southeastern corner of the central campus, adjacent to the UT School of Nursing and to the Dell Seton Medical Center at The University of Texas—the new $295 million, 211-bed teaching hospital that Seton Healthcare built.

[12][13] In late 2011, Texas Senator Kirk Watson created a list of ten health-care centered goals he hoped to achieve within ten years for his Central Texas district.

In November 2012, Travis County voters approved a proposition to raise property tax revenue in support of health care initiatives for Central Texas, including $35 million annually for a medical school.