[3] From 1883 through 1885, the play toured the U.S. Midwest and Canada, and Fox was chaperoned by Nellie Page (a leading lady) and tutored by Thomas.

In the late 1880s, she appeared with Comley Barton and the Bennett and Moulton Opera Company, with which she played soprano roles in operettas such as Fra Diavolo, The Bohemian Girl, The Pirates of Penzance, Billee Taylor and The Mikado.

Her operetta roles brought her to the attention of Heinrich Conried, who had her play Yvonne, the soubrette part in The King's Fool, singing the song "Fair Columbia".

[6] When the newly formed DeWolf Opera Company was seeking a supporting cast, George W. Lederer of the New York Casino Theatre suggested Fox.

In 1894 she starred as Clairette in William Furst's The Little Trooper, and in 1895 in the same composer's Fleur-de-Lis, continuing to play in comic opera and operetta.

[7] Beginning in 1899, Fox suffered from ill health and the effects of alcohol and drug abuse, and on October 28, 1899, she was reported to be dying of peritonitis, but survived and returned to the stage.

Her Blanche was a delightful creation throughout, but best remembered is the "athletic duet" in which she and Hopper gave amusing pantomimic representations of games of billiards, baseball, and other familiar sports.

She was cute, impish, and jaunty in turn as the Crown Prince, and, in addition, was a picture never to be forgotten in her perfect fitting white flannel suit, worn in the second act.

"[12] Of Panjandrum, an unnamed New York Times reviewer wrote that [Hopper] "gets a peculiar sort of assistance from Miss Della Fox, who can neither act nor sing and who is not pretty, but who rejoices in a marvelous popularity.

"[13] Yet a subsequent reviewer (also unnamed) wrote: [Fox's] songs and dances are encored until the little woman is forced from sheer weariness to decline further responses.

She only has to move her foot and the house feels happy, she has only to wink her eye and it laughs, she has only to faint on a barrel and hundred of people are carried away by convulsions of laughter.

[15]Philip Hale wrote of her role in Fleur-De-Lis: Disagreeable qualities in the customary performance of Miss Fox were not nearly so much in evidence as in some of her other characters.

She has a continual childish sparkle of humor, never failing under trials submerging the usual woman, and her distresses are as comic as her escapades of fun.