Later, when constitutional reforms in 1528 gave rise to the aristocratic Republic of Genoa and the ancient factions were formally abolished, the Delle Piane family were included in the Liber Nobilitatis.

The most eminent branch of the family, which originated in Polcevera, still flourishes today, and continues to produce prominent entrepreneurs both in the socioeconomic life of Genoa and in a broader international context.

The first member to hold significant posts in the government of the Republic was Oberto's son, Matteo, who is cited in official documents relating to the foundation of the church of San Nicolosio in Genoa (1305).

Various historic documents between the 12th and 13th centuries reveal that many members of the family held public office or devoted themselves to an ecclesiastical or military career, while for a long time also engaging in mercantile activities.

Many are also cited as being overseas in the 13th–14th centuries: Ottolino[14][15] (1277) a Laiazzo, an important port in the Armenian Kingdom of Cilicia; Matteo (1298) an official in Gazaria, a Genoese colony in the Crimea, and in Bonifacio in Corsica, etc.

For this reason, many members of the family served on the Magnificent Council of Elders, the leading government magistracy flanking the doges or, during periods of foreign rule, the royal or ducal governors.

[28][17] Between the 14th and 16th centuries, the members of the family did not just hold prominent posts in the government of the Republic, and in the upper echelons of the military, but also continued trading and entrepreneurial activities, both in the dominions and overseas.

Similar to clans, the members were united by common political and economic interests and used their cohesion to exert greater influence in public life and in the main trading bases.

[43] The social structure of the Republic of Genoa, definitively established by the Leges Novae enacted in 1576 following the civil war between "old" and "new" nobility in 1575 – the final resurgence of centuries of factional strife which, in the city and even more so on the Riviera and inland, had long survived the reform of 1528 – lasted until 1797.

They continued to live in part in Novi, where the family owned some of the most prestigious palaces that still characterise the historic centre of Novi (including the Palazzo Delle Piane and Villa Delle Piane, formerly Brignole-Sale), and continued to be active in the textile industry; and in part in Genoa, where they participated in the entrepreneurial and financial activities favoured by the House of Savoy and which led to an economic revival that played an important role in the Unification of Italy.

For centuries the Delle Piane family were members of the medieval civic nobility, of the landed lords typical of ecclesiastical vassalage, and subsequently of the sovereign aristocracy of Genoa.

Although outside Genoa's dominions or at foreign royal courts Genoese noblemen were treated as equivalent to the rank of Marquess, they continued to proudly use the title of Magnifico Patrizio Genovese.